Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 16533339
Gene Name FAS
Condition Endometriosis
Association Associated
Sex Female
Associated genes CD56, CD95, CD69
Other associated phenotypes Endometriosis
Aberrant expression of CD95 and CD69 molecules among CD56 cells in women with endometriosis.

Am J Reprod Immunol. 2006 Apr;55(4):276-81.

Eidukaite, Audrone| Siaurys, Almantas| Tamosiunas, Vytas

Department of Molecular Immunology, Institute of Immunology, Vilnius, Lithuania. elza@takas.lt

PROBLEM: Activated lymphocytes can be eliminated by Fas/Fas ligand (FasL)-induced cell death. Endometrial cells express FasL. The aim of our study was to determine the expression of CD56+ cells (natural killer and natural killer T cells) Fas antigen CD95 and the early activation molecule CD69 in the peritoneal fluid of women with endometriosis. METHOD: Two-colour flow cytometry was used. RESULTS: In the early stages of endometriosis, more CD56+ cells expressed CD69 and CD95 molecules when compared with the control group. However, in case of severe endometriosis the percentage of CD95+CD56+ cells in peritoneal fluid was similar to that of the control group, but the expression of CD69 molecules remained high. CONCLUSION: Because of Fas/FasL mechanisms, in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated, thus providing conditions for the survival of ectopic endometrial cells and the development of the disease.

Mesh Terms: Adult| Antigens, CD/*biosynthesis| Antigens, CD56/*biosynthesis| Antigens, CD95/*biosynthesis| Antigens, Differentiation, T-Lymphocyte/*biosynthesis| Ascitic Fluid/cytology/immunology| Endometriosis/*immunology/*metabolism/pathology| Female| Human